Carey L Scortichini

6340761, Jan 22, 2002

Nov 29, 2000

09/725298

Richard C. Krauss - Midland MI
Robert M. Strom - Midland MI
Carey L. Scortichini - Sanford MI
William J. Kruper - Sanford MI
Richard A. Wolf - Midland MI
Weishi W. Wu - Midland MI
Albert A. Carr - Cincinnati OH
David A. Hay - Cincinnati OH
Duane E. Rudisill - West Chester OH
Gianbattista Panzone - Cornaredo, IT

Merrell Pharmaceuticals Inc. - Bridgewater NJ

C07D21114

546239, 546240, 568308

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula wherein W represents —C( O)— or —CH(OH)—; R represents hydrogen or hydroxy; R represents hydrogen; R and R taken together form a second bond between the carbon atoms bearing R and R ; n is an integer of from 1 to 5; m is an integer 0 or 1; R is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R and R are taken together to form a second bond between the carbon atoms bearing R and R or where R represented hydroxy, m is an integer 0.

6348597, Feb 19, 2002

Apr 4, 2001

09/824788

Richard C. Krauss - Midland MI
Robert M. Strom - Midland MI
Carey L. Scortichini - Sanford MI
William J. Kruper - Sanford MI
Richard A. Wolf - Midland MI
Weishi W. Wu - Midland MI
Albert A. Carr - Cincinnati OH
David A. Hay - Cincinnati OH
Duane E. Rudisill - West Chester OH
Gianbattista Panzone - Cornaredo, IT

Merrell Pharmaceuticals, Inc. - Bridgewater NJ

C07D21114

546239, 544129, 546190, 546191, 546213, 546240

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula wherein W represents —C( O)— or —CH(OH)—; R represents hydrogen or hydroxy; R represents hydrogen; R and R taken together form a second bond between the carbon atoms bearing R and R ; n is an integer of from 1 to 5; m is an integer 0 or 1; R is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R and R are taken together to form a second bond between the carbon atoms bearing R and R or where R represented hydroxy, m is an integer 0.

6352635, Mar 5, 2002

Jan 12, 2001

09/760325

Karl Leopold Krumel - Midland MI
Craig Joseph Bott - Clare MI
Michael Frederick Gullo - Midland MI
Carey Lee Scortichini - Midland MI

Dow AgroSciences LLC - Indianapolis IN

C25B 300

205426

Halogen substituents in the 5-position of 4-aminopicolinic acids are selectively reduced in the presence of halogen substituents in the 3- and 6-positions by electrolysis.

6441179, Aug 27, 2002

Mar 28, 2001

09/818966

Richard C. Krauss - Midland MI
Robert M. Strom - Midland MI
Carey L. Scortichini - Sanford MI
William J. Kruper - Sanford MI
Richard A. Wolf - Midland MI
Weishi W. Wu - Midland MI
Albert A. Carr - Cincinnati OH
David A. Hay - Cincinnati OH
Duane E. Rudisill - West Chester OH
Gianbattista Panzone - Cornaredo, IT

Merrell Pharmaceuticals Inc. - Bridgewater NJ

C07D21114

546239, 546240

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula wherein W represents —C( O)— or —CH(OH)—; R represents hydrogen or hydroxy; R represents hydrogen; R and R taken together form a second bond between the carbon atoms bearing R and R ; n is an integer of from 1 to 5; m is an integer 0 or 1; R is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R and R are taken together to form a second bond between the carbon atoms bearing R and R or where R represented hydroxy, m is an integer 0.

6479663, Nov 12, 2002

Dec 1, 2000

09/726625

Richard C. Krauss - Midland MI
Robert M. Strom - Midland MI
Carey L. Scortichini - Sanford MI
William J. Kruper - Sanford MI
Richard A. Wolf - Midland MI
Weishi W. Wu - Midland MI
Albert A. Carr - Cincinnati OH
David A. Hay - Cincinnati OH
Duane E. Rudisill - West Chester OH
Gianbattista Panzone - Cornaredo, IT

Merrell Pharmaceuticals Inc. - Bridgewater NJ

C07D21114

546239, 546240

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula wherein W represents —C( O)— or —CH(OH)—; R represents hydrogen or hydroxy; R represents hydrogen; R and R taken together form a second bond between the carbon atoms bearing R and R ; n is an integer of from 1 to 5; m is an integer 0 or 1; R is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R and R are taken together to form a second bond between the carbon atoms bearing R and R or where R represented hydroxy m is an integer 0.

6566526, May 20, 2003

Nov 29, 2000

09/725291

Richard C. Krauss - Midland MI
Robert M. Strom - Midland MI
Carey L. Scortichini - Sanford MI
William J. Kruper - Sanford MI
Richard A. Wolf - Midland MI
Weishi W. Wu - Midland MI
Albert A. Carr - Cincinnati OH
David A. Hay - Cincinnati OH
Duane E. Rudisill - West Chester OH
Gianbattista Panzone - Cornaredo, IT

Merrell Pharmaceuticals Inc. - Bridgewater NJ

C07D21122

546239, 546240

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula wherein W represents —C( O)— or —CH(OH)—; R represents hydrogen or hydroxy; R represents hydrogen; R and R taken together form a second bond between the carbon atoms bearing R and R ; n is an integer of from 1 to 5; m is an integer 0 to 1; R is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R and R are taken together to form a second bond between the carbon atoms bearing R and R or where R represented hydroxy, m is an integer 0.

6548675, Apr 15, 2003

Dec 5, 2000

09/729203

Richard C. Krauss - Midland MI
Robert M. Strom - Midland MI
Carey L. Scortichini - Sanford MI
William J. Kruper - Sanford MI
Richard A. Wolf - Midland MI
Weishi W. Wu - Midland MI
Albert A. Carr - Cincinnati OH
David A. Hay - Cincinnati OH
Duane E. Rudisill - West Chester OH
Gianbattista Panzone - Cornaredo, IT

Merrell Pharmaceuticals Inc. - Bridgewater NJ

C07D21122

546239, 546240

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula wherein W represents —C( O)— or —CH(OH)—; R represents hydrogen or hydroxy; R represents hydrogen; R and R taken together form a second bond between the carbon atoms bearing R and R ; n is an integer of from 1 to 5; m is an integer 0 or 1; R is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R and R are taken to form a second bond between the carbon atoms R and R or where R represented hydroxy integer 0.

6552200, Apr 22, 2003

Nov 29, 2000

09/725259

Richard C. Krauss - Midland MI
Robert M. Strom - Midland MI
Carey L. Scortichini - Sanford MI
William J. Kruper - Sanford MI
Richard A. Wolf - Midland MI
Weishi W. Wu - Midland MI
Albert A. Carr - Cincinnati OH
David A. Hay - Cincinnati OH
Duane E. Rudisill - West Chester OH
Gianbattista Panzone - Cornaredo, IT

Merrell Pharmaceuticals Inc. - Bridgewater NJ

C07D21122

546239, 546240

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula wherein W represents —C( O)— or —CH(OH)—; R represents hydrogen or hydroxy; R represents hydrogen; R and R taken together form a second bond between the carbon atoms bearing R and R ; n is an integer of from 1 to 5; m is an integer 0 or 1; R is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R and R are taken together to form a second bond between the carbon atoms bearing R and R or where R represented hydroxy, n is an integer 0.