Carey L Scortichini

6340761, Jan 22, 2002

Nov 29, 2000

09/725298

Richard C. Krauss - Midland MI
Robert M. Strom - Midland MI
Carey L. Scortichini - Sanford MI
William J. Kruper - Sanford MI
Richard A. Wolf - Midland MI
Weishi W. Wu - Midland MI
Albert A. Carr - Cincinnati OH
David A. Hay - Cincinnati OH
Duane E. Rudisill - West Chester OH
Gianbattista Panzone - Cornaredo,

Merrell Pharmaceuticals Inc. - Bridgewater NJ

C07D21114

546239, 546240, 568308

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula wherein W represents —C( O)— or —CH(OH)—; R represents hydrogen or hydroxy; R represents hydrogen; R and R taken together form a second bond between the carbon atoms bearing R and R ; n is an integer of from 1 to 5; m is an integer 0 or 1; R is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R and R are taken together to form a second bond between the carbon atoms bearing R and R or where R represented hydroxy, m is an integer 0.

2011009, Apr 28, 2011

Oct 26, 2010

12/912216

Chen Wang - Midland MI,
Scott L. Haynes - Saginaw MI,
Carey L. Scortichini - Midland MI,

C25B 3/00

205426

The selective electrochemical reduction of halogenated 4-aminopicolinic acids is improved by activating the cathode at a final potential from about +1.0 to about +1.8 volts.

5246561, Sep 21, 1993

Jan 26, 1993

8/008954

Carey L. Scortichini - Sanford MI
Janeth M. Bartlett - Midland MI

The Dow Chemical Company - Midland MI

G01N 2730

204415

An electrolytic cell for the labeling of proteins, peptides and other organic molecules employs a cathodic half cell and an anodic half cell, where a porous working electrode is located in one half cell and a counter electrode is located in the other of the half cell, the two half cells being divided by a separator. A reference electrode located in the half cell containing the working electrode, and placed outside the current path between the working electrode and the counter electrode confers precise control of the working electrode potential, which allows the maximum rate of labeling to be achieved while minimizing oxidative damage to the protein, peptide or organic molecules. Saturation of the working electrode with non-radioactive label coupled with a ratio of working electrode surface area to volume of half cell containing the working electrode between 0. 001 cm. sup. -1 to about 10 cm. sup. -1 minimizes the problem of loss of activity of radiolabel due to adsorption on the working electrode.

6103413, Aug 15, 2000

May 21, 1998

9/082931

Carlos E. Hinton - Midland MI
Carey L. Scortichini - Midland MI
Robert D. Mussell - Midland MI

The Dow Chemical Company - Midland MI

H01M 648
H01M 824

429 32

A bipolar separator plate for two electrochemical cells connected in series, the plate having two layers of a porous electronically conductive material having positioned therebetween a solid layer of a polymeric material having dispersed therein at least 1 percent by weight of a conductive filler, wherein the plate has an area resistivity of less than 1 ohm-cm. sup. 2, and wherein the solid layer has a permeability of less than 50. mu. Darcy (. mu. D).

6147216, Nov 14, 2000

Jun 2, 1995

8/458747

Richard C. Krauss - Midland MI
Robert M. Strom - Midland MI
Carey L. Scortichini - Sanford MI
William J. Kruper - Sanford MI
Richard A. Wolf - Midland MI
Weishi W. Wu - Midland MI
Albert A. Carr - Cincinnati OH
David A. Hay - Cincinnati OH
Duane E. Rudisill - West Chester OH
Gianbattista Panzone - Cornaredo,

Merrell Pharmaceuticals Inc. - Bridgewater NJ

C07D21114
C07C 49792
C07C 4980

546239

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula ##STR1## wherein W represents --C(. dbd. O)-- or --CH(OH)--; R. sub. 1 represents hydrogen or hydroxy; R. sub. 2 represents hydrogen; R. sub. 1 and R. sub. 2 taken together form a second bond between the carbon atoms bearing R. sub. 1 and R. sub. 2 ; n is an integer of from 1 to 5; m is an integer 0 or 1; R. sub. 3 is --COOH or --COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R. sub. 1 and R. sub. 2 are ta to form a second bond between the carbon R. sub. 1 and R. sub. 2 or where R. sub.

6312845, Nov 6, 2001

May 23, 1997

8/862273

Carey L. Scortichini - Midland MI
Robert D. Mussell - Midland MI
Susan J. Babinec - Midland MI

The Dow Chemical Company - Midland MI

H01M 496
H01M 804

429 30

An electrochemical fuel cell having a membrane electrode assembly and a flow field adjacent thereto wherein the flow field comprises an electrically conductive porous material having a porosity of at least about 50 percent and a mean pore size of at least about 35 microns. This fuel cell is able to operate at relatively high current densities and relatively high voltages at reduced gas flow rates.

6242606, Jun 5, 2001

Jul 14, 1994

8/275685

Richard C. Krauss - Midland MI
Robert M. Strom - Midland MI
Carey L. Scortichini - Sanford MI
William J. Kruper - Sanford MI
Richard A. Wolf - Midland MI
Weishi W. Wu - Midland MI
Albert A. Carr - Cincinnati OH
David A. Hay - Cincinnati OH
Duane E. Rudisill - West Chester OH
Gianbattista Panzone - Cornaredo,

Merrell Pharmaceuticals Inc. - Bridgewater NJ

C07D21114

546239

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula ##STR1## wherein W represents --C(. dbd. O)-- or --CH(OH)--; R. sub. 1 represents hydrogen or hydroxy; R. sub. 2 represents hydrogen; R. sub. 1 and R. sub. 2 taken together form a second bond between the carbon atoms bearing R. sub. 1 and R. sub. 2 ; n is an integer of from 1 to 5; m is an integer 0 or 1; R. sub. 3 is --COOH or --COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R. sub. 1 and R. sub. 2 are taken together to form a second bond between the carbon atoms bearing R. sub. 1 and R. sub. 2 or where R. sub.

5620807, Apr 15, 1997

Aug 31, 1995

8/522482

Robert D. Mussell - Midland MI
Steven P. Webb - Midland MI
Carey L. Scortichini - Midland MI
Keith R. Plowman - Lake Jackson TX

The Dow Chemical Company - Midland MI

H01M 810

429 33

An electrochemical fuel cell having a membrane electrode assembly and a layer of an electrically conductive porous material adjacent thereto which has at least two portions with different mean pore sizes, wherein a first portion of the layer adjacent to the membrane electrode assembly has a porosity no greater than a second portion of the layer adjacent to the opposite side of the layer; the second portion has a porosity of at least about 82 percent; and the second portion has an mean pore size which is at least about 10 microns and at least ten times greater than the mean pore size of the first portion.