Inventors:
Richard C. Krauss - Midland MI
Robert M. Strom - Midland MI
Carey L. Scortichini - Sanford MI
William J. Kruper - Sanford MI
Richard A. Wolf - Midland MI
Weishi W. Wu - Midland MI
Albert A. Carr - Cincinnati OH
David A. Hay - Cincinnati OH
Duane E. Rudisill - West Chester OH
Gianbattista Panzone - Cornaredo, IT
Assignee:
Merrell Pharmaceuticals, Inc. - Bridgewater NJ
International Classification:
C07D21114
US Classification:
546239, 544129, 546190, 546191, 546213, 546240
Abstract:
The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula wherein W represents âC( O)â or âCH(OH)â; R represents hydrogen or hydroxy; R represents hydrogen; R and R taken together form a second bond between the carbon atoms bearing R and R ; n is an integer of from 1 to 5; m is an integer 0 or 1; R is âCOOH or âCOOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R and R are taken together to form a second bond between the carbon atoms bearing R and R or where R represented hydroxy, m is an integer 0.