Ge Li

6432959, Aug 13, 2002

Dec 22, 1999

09/469465

Alan B. Cooper - West Caldwell NJ
Ronald J. Doll - Maplewood NJ
Johan A. Ferreira - Bensalem PA
Ashit Ganguly - Upper Montclair NJ
Viyyoor M. Girijavallabhan - Parsippany NJ
Arthur G. Taveras - Denville NJ
Jianping Chao - Summit NJ
John J. Baldwin - Gwynedd Valley PA
Chia-Yu Huang - Plainsboro NJ
Ge Li - Lawrenceville NJ

Schering Corporation - Kenilworth NJ

A61K 31496

51425309, 51425402, 51425405, 544364, 544367, 544370

Novel compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel aminooxyamide compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.

6797522, Sep 28, 2004

Mar 12, 1998

09/041343

W. Clark Still - New York NY
Ge Li - Plainsboro NJ
Helma Wennemers - New York NY

The Trustees of Columbia University in the City of New York - New York NY

G01N 33566

436518, 436501, 436528, 436529, 436531, 436534, 530334, 536 253, 544 1, 544 2, 548100

The invention is directed to synthetic receptor(s) which comprises a polyfunctional organic template covalently linked to two or more oligomers which may independently be the same or different and may independently be straight chain, cyclic or branched. The template may be linked to an identifier which uniquely defines the synthetic receptor. The identifier is a stable chemical molecule or a plurality of stable chemical molecules distinguishable and detectable to picomolar levels or may be an oligonucleotide. In a preferred embodiment, the template is covalently linked to a solid support which is linked to an identifier. In addition, the invention includes methods of preparing synthetic receptors and synthetic receptor libraries. The synthetic library may be linked with identifiers such that the library comprises a plurality of different synthetic receptor members. The invention also provides methods for assaying a synthetic receptor library to determine suitable synthetic receptor(s) which (a) bind an acceptor molecule; (b) exhibit biological activity; (c) which catalyze a reaction or inhibit a catalyzed reaction; and (d) separate compounds in chromatography.

7067326, Jun 27, 2006

Jan 13, 1995

08/676143

W. Clark Still - New York NY, US
Ge Li - Plainsboro NJ, US
Helma Wennemers - Bruchkoebel, DE

The Trustees of Columbia University in the City of New York - New York NY

G01N 33/543
C07K 5/00
C07H 21/04

436518, 530333, 530334, 536 111, 536 231, 435 6, 435DIG 1, 435DIG 22, 435DIG 34, 435DIG 40

Libraries of synthetic receptors are disclosed. The receptors include a polyfunctional organic template which is covalently linked to two or more oligomers. The oligomers may be the same or different and may be straight chain, cyclic or branched. The template may be linked to an identifier which is unique to each synthetic receptor. Although the identifier may be directly attached to the template, it is more common and preferable that the template be covalently linked to a solid support which is itself linked to the identifier. Methods of preparing synthetic receptors and libraries of synthetic receptors are also disclosed as are methods for assaying the libraries to determine which receptors have various desirable characteristics. Among the desirable characteristics are (a) the ability to bind an acceptor molecule; (b) biological activity; (c) the ability to catalyze or inhibit a reaction and (d) potential utility for separating compounds in chromatography.

58011757, Sep 1, 1998

Sep 13, 1996

8/713324

Adriano Afonso - West Caldwell NJ
John J. Baldwin - Gwynedd Valley PA
Ronald J. Doll - Maplewood NJ
Ge Li - Franklin Park NJ
Alan K. Mallams - Long Valley NJ
F. George Njoroge - Union NJ
Dinanath F. Rane - Morganville NJ
John C. Reader - Princeton NJ
Randall R. Rossman - Nutley NJ

Schering Corporation - NJ
Pharmacopeia, Inc. - DE

A61K 31495
A61K 31505
C07D40314
C07D40114

514254

Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the above formula to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.

62148273, Apr 10, 2001

Jun 23, 1998

9/108124

Adriano Afonso - West Caldwell NJ
John J. Baldwin - Gwynedd Valley PA
Ronald J. Doll - Maplewood NJ
Ge Li - Franklin Park NJ
Alan K. Mallams - Long Valley NJ
F. George Njoroge - Union NJ
Dinanath F. Rane - Morganville NJ
John C. Reader - Princeton NJ
Randall R. Rossman - Nutley NJ

Schering Corporation - Kenilworth NJ

A61K 31495
A61K 31445
A61P 3500
C07D40100
C07D24102

51425213

Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the above formula to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.

58801286, Mar 9, 1999

May 8, 1996

8/646835

Ronald J. Doll - Maplewood NJ
Alan K. Mallams - Hackettstown NJ
Adriano Afonso - West Caldwell NJ
George F. Njoroge - Union NJ
Randall R. Rossman - Nutley NJ
John J. Baldwin - Gwynedd Valley PA
Ge Li - Englewood NJ
John C. Reader - Princeton NJ

Schering Corporation - Kenilworth NJ
Pharmacopeia Inc. - Princeton NJ

C07D29518
A61K 31495

514255

Novel carbonyl piperazinyl and piperidinyl compounds and pharmaceutical compositions are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel carbonyl piperazinyl or piperidinyl compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.